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Thanks to efforts to create effective anti-aging interventions to extend lifespan, people worldwide live longer than ever. But, are we living better? Research has shown that enhancing NAD+ biosynthesis with NMN can improve age-associated health problems during the natural aging process. Let’s learn the essential NMN benefits in healthy aging.
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Achieve Healthy Aging – Learn 7 Proven NMN Benefits & Its Side Effects
NMN (nicotinamide mononucleotide) is required to produce NAD+, a critical coenzyme found in every cell in your body. NAD+ helps transform nutrients into energy in metabolism and assists the proteins that regulate other cellular processes.
NMN supplementation has remarkable therapeutic effects on treating metabolic problems and other diseases. Here’s how NMN can boost your health in a variety of ways.
Increases Energy Metabolism and Physical Activity
The first NMN benefit is increasing energy metabolism and physical activity. Energy metabolism is the process of producing energy from nutrients. According to research, NMN has significant preventive effects against age-associated degradation in energy metabolism and can stimulate physical activity in mice.
According to another study on treating 18-month-old mice with NMN, the animal subjects showed a 56 to 80 percent improvement in endurance after two months. Beneficial effects were also seen in mice up to 32 months old, equivalent to humans in their 80s.
Improves Brain Function
Balanced brain function requires a sufficient supply of oxygen and nutrients. Despite accounting for only 2 percent of total body mass, the human brain needs 20 percent of total resting body oxygen. Cerebral blood flow to active brain areas ensures enough oxygen and nutrients to carry out its functions.
As a result, balanced brain functioning is only achievable if cerebral blood flow is unimpeded. Research provides evidence that NMN administration enhances brain function in aged mice by increasing brain blood vessel dilatation and blood flow to the brain.
Improves Eye Function
The loss of NAD+ levels causes rapid neurodegeneration in the eye and vision loss. Replenishing NMN can prevent negative consequences and restore vision. According to research, long-term NMN administration significantly enhances eye function and tear production. Another study showed that NMN could also protect eye cells and reduce inflammation in dry eye disease by triggering DNA maintenance and a health-promoting protein.
Prevents Heart Failure
Heart failure is associated with mitochondrial dysfunction. It is critical to restore or improve mitochondrial health to prevent heart failure. Research has shown that short-term administration of NMN successfully protected the mutant mice against heart failure by protecting mitochondrial ultrastructure and avoiding cell death in the heart. The findings have also concluded that NMN administration can be a promising therapy for cardiac diseases.
RELATED: Nicotinamide Adenine Dinucleotide (NAD+) Deficiency May Cause Mortality Among COVID-19 Patients
Suppresses Age-associated Body Weight Gain
Human muscle mass declines as we get older, but our fat mass grows. This fat mass growth is one of the causes of age-associated body weight gain. According to research, NMN administration significantly suppressed age-associated body weight gain in mice after 12 months without any sign of apparent toxicity. The results also showed that the effect of NMN on body weight was not due to a growth problem or loss of appetite.
Improves Insulin Sensitivity
Insulin sensitivity refers to how sensitive the body’s cells react to insulin. High insulin sensitivity helps the body cells use blood glucose more effectively, resulting in lower blood sugar levels. In contrast, low insulin sensitivity can progress to type 2 diabetes and weight gain. According to research, long-term NMN administration can reduce the age-associated decline in insulin sensitivity in mice.
Improves Fertility
An oocyte is an immature egg cell that eventually develops into a maternal egg. The quality of oocytes decreases as the female body ages. According to research, NMN benefits fertility by enhancing the number and quality of maternal eggs and fertilizing them in mice. The findings provide a potential approach to improving women’s reproductivity in their late maternal years.
Only a few pre-clinical and clinical investigations on NMN side effects have been conducted to date. Human clinical trials are in progress to determine the safety of NMN supplementation, but the findings have yet to be released. More research on NMN administration in humans is necessary to find out any adverse effects from consuming it.
NAD+ depletion has been linked to several diseases. By increasing NAD+ levels in the body, NMN, as the precursor of NAD+, can reverse age-related complications and slow down the process of aging.
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