Yes and no. Ozempic has been linked to a higher chance of erectile dysfunction and testosterone deficiency, but it’s not a guaranteed outcome. And like all solid science, it’ll take more time and studies to get a clear answer.
Should you be worried? Let’s dive into when you should talk to your doctor about erectile dysfunction while using this injectable.

What Is Ozempic and How Does It Work?
Ozempic (semaglutide) is a medication designed to help manage type 2 diabetes by lowering blood sugar levels. It’s a GLP-1 receptor agonist, which means it boosts insulin production and keeps glucose in check. It also helps with weight loss, so it tackles two problems at once.
The hypothalamus is where Ozempic works its magic for hunger and satiety, but it’s also a key player in sexual desire. So, while it’s primarily known for controlling your appetite, it’s not far-fetched to think that Ozempic could affect your libido too.
Link Between Ozempic and Sex Drive: What Does the Research Say?
Some studies suggest that semaglutide might increase the risk of erectile dysfunction (ED), but don’t freak out just yet.
A 2024 study found that non-diabetic men using semaglutide had a higher chance of developing ED and testosterone deficiency. However, the rates were still low—only 1.4%.
In a similar 2021 study, the numbers were slightly higher, with a 1.5% increase in ED and hypogonadism in non-diabetic men. These findings were presented at the Sexual Medicine Society of North America’s meeting, so they’re worth noting, but still considered a low percentage overall.
Here’s the thing: GLP-1 drugs like semaglutide mainly target appetite and metabolism, but they affect other areas too. That’s because the brain regulates both hunger and sexual desire through the same pathways. So, it’s possible that these drugs could mess with your libido.
Plus, poorly controlled diabetes can also impact sexual health and drive, making it even harder to pinpoint the exact cause.
Can Weight Loss Drugs Cause Erectile Dysfunction?
Yes, weight loss drugs can mess with your bedroom game. It’s not just Ozempic or Wegovy—plenty of medications can affect sexual health.
All of these drugs have been linked to erectile dysfunction:
- anti-depressants
- anti-androgen drugs, like 5-alpha reductase inhibitors
- blood pressure medications, such as beta-blockers and thiazide diuretics
- opioid painkillers
- antihistamines
- chemotherapy drugs
It’s not always a black-and-white situation.
If you’re noticing a dip in sex drive after taking Ozempic or any GLP-1 receptor agonist, it’s worth chatting with your doctor. Your doctor might adjust your dosage or prescribe a better drug for you.

When Should You Be Concerned About Sexual Side Effects?
If you’re noticing any sexual side effects, it’s time to pay attention. Here’s when you should take action:
- If it’s persistent: If the issue drags on for weeks or months, it’s time to speak up.
- If it’s impacting your life: If these side effects are messing with your mood, relationships, or overall well-being, don’t brush it off.
- If it’s getting worse: If things aren’t improving or new issues pop up, get checked out.

What To Do
- Talk to your doctor: Be upfront. The sooner you discuss it, the quicker you can tackle the problem.
- Don’t stop meds cold turkey: Never stop without consulting your doctor. They’ll help you adjust or switch if needed.
- List down all other medications you’re taking: Other health factors or medications could be contributing.
Possible Solutions
Adjusting your medication: Your doctor might suggest lowering the dose or switching things up.
Lifestyle tweaks: Better food, more exercise, and stress reduction can work wonders.
Counseling or therapy: If it’s mental, sometimes talking helps more than anything.
Treatments for ED: Meds or devices might be the answer if you’re dealing with ED.
Don’t just accept the side effects. These meds are powerful, but there are plenty of other ways to lose weight, like changing up your diet, hitting the gym, or trying a different medication. There are as much as six FDA-approved weight loss drugs, including semaglutide (Ozempic and Wegovy).
The point is, science is always evolving, and you’re not stuck with one solution.
Let’s figure it out together—don’t let side effects knock you down. Your health is a journey, and there’s always another option waiting for you.
Take Control of Your Hormonal Health
Hormones are like the conductors of a finely tuned orchestra, managing a symphony of functions, organ systems, and bodily processes all at once. Changing one hormone can affect another—take testosterone, for example. When it’s out of balance, it can ripple through other aspects of your health, including weight management and sexual well-being.
At Yunique Medical, we take a holistic approach to hormone health, helping you navigate the intricate relationship between your hormones, weight, and overall vitality. Our experts work with you to track your progress, adjust treatments as needed, and make sure you’re achieving optimal results across the board—whether it’s in your weight loss journey, sexual health, or general well-being.
Contact Yunique Medical today to learn how we can create a personalized plan that supports your weight loss goals, sexual health, and overall well-being.