AI Can Spot Hidden Heart Disease Before It Strikes

Heart disease remains the leading cause of death in the United States, claiming nearly 700,000 lives each year, more than all forms of cancer combined. Many people who appear healthy may already have plaque building up silently within their arteries. In fact, over half of first-time heart attacks happen in people who had no prior warning signs. The ability to detect hidden heart disease before it strikes could save countless lives.

At Yunique Medical, we believe prevention is the most powerful form of care. Through our HeartFit Program, we’re transforming how cardiovascular risk is assessed and managed. Using Cleerly AI, a groundbreaking imaging technology, we can visualize plaque inside your arteries with unmatched precision, long before it causes harm. This article explains how this technology works and why early detection is crucial for maintaining long-term heart health.

How Cleerly AI can spot hidden heart disease

What Cleerly AI is

Cleerly AI is an FDA-cleared imaging tool that uses artificial intelligence to analyze your coronary computed tomography angiography (CCTA) scans in detail. Unlike traditional tests that focus only on how much your arteries are narrowed (stenosis), Cleerly AI quantifies plaque composition, volume, and distribution throughout your coronary arteries. It also differentiates between calcified and non-calcified plaque, the kind most likely to cause a heart attack.

This approach allows your care team to see beyond what standard imaging reveals. Instead of simply identifying whether arteries are blocked, Cleerly AI shows where hidden disease exists, how advanced it is, and what types of plaque pose the greatest threat. This data-driven insight allows for personalized prevention strategies tailored to your unique cardiovascular profile.

What the latest studies show

The power of Cleerly AI was recently highlighted in a large-scale international study, known as the CONFIRM2 Registry, presented at the 2025 Transcatheter Cardiovascular Therapeutics (TCT) Conference. Researchers analyzed more than 6,500 patients using AI-guided plaque evaluation. They found that individuals who experienced heart attacks or death had nearly five times more non-calcified plaque than those who did not.

Even more striking, many cardiac events occurred in patients who didn’t have obstructive coronary artery disease, meaning their arteries weren’t significantly narrowed. These findings show that traditional testing methods often miss patients at risk, while AI-powered analysis can identify vulnerable plaque long before it becomes symptomatic. Cleerly AI can provide a deeper, more accurate understanding of who is truly at risk.

How Cleerly AI works

Cleerly AI starts with a noninvasive CT scan that produces high-resolution images of your heart and arteries. The software’s AI algorithms then perform quantitative analysis, measuring the precise amount and type of plaque present. It identifies soft (non-calcified), mixed, and hard (calcified) plaque, calculates total plaque volume, and maps areas of arterial remodeling.

You receive a clear, easy-to-understand visual report that displays where plaque exists and how your heart’s condition compares to healthy benchmarks. From there, your care team develops a precision-based prevention plan, combining lifestyle adjustments, nutritional support, and targeted therapies to reverse or stabilize plaque formation before it leads to a heart attack.

The importance of detecting heart disease at the earliest stage

Early detection saves lives

Catching heart disease early can dramatically reduce your risk of serious complications. Once plaque buildup becomes severe enough to restrict blood flow, the damage to your heart muscle may be irreversible. With early detection through Cleerly AI and the HeartFit Program, you can take proactive steps, such as adjusting diet, managing inflammation, and optimizing key biomarkers, before irreversible damage occurs.

Traditional tests often miss silent threats

Common tests, such as stress tests or cholesterol screenings, don’t always tell the full story. You might have normal cholesterol yet still harbor unstable plaque in your arteries. Traditional angiography detects only blockages that limit blood flow, not the dangerous, non-calcified plaque that can rupture suddenly and cause a heart attack. Cleerly AI fills this diagnostic gap, identifying hidden threats long before they cause symptoms.

Prevention is more effective than treatment

By the time chest pain, fatigue, or shortness of breath develop, heart disease may already be advanced. Preventive cardiology focuses on stopping disease before it starts. With AI-based diagnostics, Yunique Medical can identify risks and implement interventions such as targeted nutrition, peptide therapy, and lifestyle modification early enough to change the trajectory of your heart health and prevent complications down the line.

Personalized data drives better outcomes

Every heart is unique. AI-based imaging allows your care team to understand your risk factors in remarkable detail. Whether your primary issue is inflammation, genetics, or oxidative stress, a personalized plan based on precise imaging data ensures that your care is built specifically for you. This precision enables measurable improvement in both plaque stability and long-term cardiovascular wellness.

The future of preventive cardiology

The integration of artificial intelligence into cardiovascular care represents a major leap forward in preventive medicine. Instead of relying on reactive treatment after a heart attack, tools like Cleerly AI allow us to intervene decades earlier, preventing disease progression entirely.

At Yunique Medical, the HeartFit Program utilizes this next-generation diagnostic technology in conjunction with our holistic, personalized approach to wellness. We focus on optimizing heart health before symptoms appear, giving you the tools and insights to live longer, stronger, and more vibrantly. Take charge of your heart health today with AI-powered detection.