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Effects of Tesamorelin on Anti-aging and Longevity

By May 8, 2022No Comments

Treatment involving growth hormone has long gained a widespread consensus as a promising “fountain of youth” to produce anti-aging benefits and achieve longevity. Among the emerging treatment options, tesamorelin shows its amazing positive effects on anti-aging and longevity, opening the door to increasing the quality of life for many people.

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Tesamorelin: a Potential Peptide for Anti-aging and Longevity

As people age, the body suffers from a deficiency of hormones, which are vital to many bodily functions. Further, older adults without proper physical activities tend to develop fat in the abdomen while losing considerable muscle mass every year. The decline in cognitive function is another negative aspect of aging, preventing older people from functioning at an average level.

On this account, a promising peptide known as tesamorelin is under investigation for usage in peptide therapy to assist the senior population in preserving a better quality of life.


What Is Tesamorelin?

Human growth hormone

Tesamorelin (marketed as Egrifta) is an injectable peptide that acts as a growth hormone-releasing hormone (GHRH) analog. Simply put, it is the synthetic version of the GHRH. Administration of tesamorelin into the body can increase growth hormone via a chain reaction, potentially promoting longevity and restoring youthful health.

Human growth hormone is produced in the pituitary gland. It plays a significant role in many physiological processes, including normal development in children, body composition regulation, muscle and bone growth, sugar and fat metabolism, and heart function. Since growth hormone levels in humans naturally decrease with age, a synthetic peptide that can increase growth hormone may reverse the age-related deterioration of the body. On this account, tesamorelin is expected to affect anti-aging and longevity positively.


How Does Tesamorelin Work?

After administered into the body, tesamorelin peptide binds to and stimulates the GHRH receptors in the pituitary gland, which then releases the GHRH at a regulated level through a feedback loop. Afterward, GHRH stimulates the natural production of the growth hormone. The GHRH produced by tesamorelin has similar potency as the naturally occurring GHRH, resulting in various beneficial effects while being generally safe.


What Are the Effects of Tesamorelin?

Restoring Growth Hormone

Growth hormone declines progressively with aging, leading to various age-related health problems, among many other hormones. This group of geriatric conditions includes an increase in body fat, a decrease in lean muscle mass, and a reduction in cognitive function. By stimulating the pituitary gland and subsequently releasing GHRH, tesamorelin helps restore growth hormone to normal levels. Thereby, tesamorelin directly targets abdominal fat and reverses the age-related conditions, as discussed below.


Reducing Visceral Fat

Research shows that tesamorelin may increase the oxidation of visceral fat by increasing growth hormone. Fat oxidation refers to the breakdown of stored fat into fatty acids, which are then converted into fuel for body functions. In other words, tesamorelin can help burn fat around the abdominal organs and use it as energy. Significantly, tesamorelin does not affect fat tissue under the skin. This selective reduction in fat is beneficial since it helps protect against or prevents the worsening of abnormal distribution of fat into other organs.


Preserving Lean Muscle Mass

A study showed that treatment with growth hormone medications in deficient adults could restore muscle strength. The beneficial effects were more significant in younger individuals. Therefore, by acting as a GHRH analog, tesamorelin may increase and normalize the amount of lean muscle mass in both young people with growth hormone deficiency and healthy older adults. Remember that tesamorelin has not been shown to aid in building muscle; hence the usage of this peptide in bodybuilding is not recommended.


Improving Cognitive Function

According to a study, tesamorelin can significantly improve the ability to solve problems, maintain attention, make plans, and memorize words in healthy older adults and those with minimal cognitive impairment. By restoring normal growth hormone, tesamorelin may benefit synaptic plasticity, which increases mental capacity. However, a longer duration of the treatment is necessary to examine the potential of tesamorelin on brain health during normal aging.

The effects of tesamorelin may not last after discontinuation of the peptide. Therefore, long-term use of tesamorelin over six months may be preferred for maintaining positive outcomes.

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Is Tesamorelin Safe?

Since tesamorelin naturally stimulates growth hormone production, this peptide is generally safe. Some potential side effects of tesamorelin include:

  • Muscle pain
  • Skin redness and rash at the injection site
  • Joint pain
  • Stomach pain
  • Swelling


Administration of tesamorelin may also cause the glucose levels in the body to increase slightly, leading to minimal changes in insulin sensitivity. However, the peptide does not result in insulin resistance, and long-duration use of tesamorelin can reverse glucose to normal levels.

Although the use of tesamorelin has not yet been approved for the purpose of anti-aging and longevity, it was approved by the FDA for reducing visceral fat among individuals with a condition regarding the deficiency of the immune system. Please remember that tesamorelin is not indicated for weight loss and may have no effect on overall weight.

In conclusion, tesamorelin is a promising candidate for treating a wide range of age-related conditions to achieve longevity. Although further research is required until this peptide can be available for a larger population, the way to the “fountain of youth” is on the horizon.


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